Introducing our Pioreactor 20ml dosing platform

Introducing our Pioreactor 20ml dosing platform
We love compactness. We love when things just fit together. We love protocols! We love open source design! Which is why we put all four of these ideas into our new Pioreactor dosing platform: 

What is (lab) directed evolution?

What is (lab) directed evolution?
Directed evolution is the technique of controlling an organism's evolutionary trajectory such that its descendants have more of a desired properties. Most often, the engineers will have a strict control of the organism's environment. By controlling the environment and responding to the organism's simultaneous adaption, an organism can be directed to have novel or desirable properties

One last blogpost from your favourite employee #3

One last blogpost from your favourite employee #3
With the end of September approaching, we're on track to soon assemble and send off our first batch of Pioreactors — and it also marks the end of my internship! in this blog post, I'll discuss my experiences over the summer and announce some fun projects we've completed in the last few weeks. 

More on Plugins

More on Plugins
We’ve discussed a bit before on using plugins to customize your experience with the Pioreactor. Let’s walk through how to make one, where to install it, and introduce two new plugins we created that are available on our web interface.

Using custom automations to control your Pioreactor

Using custom automations to control your Pioreactor
Inspired by this paper by Knutson et al., (2018), we created a new temperature automation that cycles temperature as a sine wave between 30°C and 40°C over 24 hours. With this new automation, and in our expanded Pioreactor/turbidostat system, we grew some yeast over the weekend – and the findings are quite interesting! 

Pioreactor dev blog #19 - New hardware pages

Pioreactor dev blog #19 - New hardware pages
We've been working with a cluster of prototype Pioreactors with slight build modifications, but we have settled on an optimized design. As such, we've recently updated our documentation site to include a new hardware setup section in our User Guide. Check it out!

Pioreactor dev blog #18 - Vial holder

Pioreactor dev blog #18 - Vial holder

Another cool thing we designed is a special vial holder, so you can organize your experiments with ease. 

We allocated 4 slots for vials and are in the process of creating holders of varying sizes. It has a wider bottom versus top for more stability, and debossing under each vial to mitigate potential slipping. It also includes a deboss of our logo!

Pioreactor dev blog #17 - Noisy data

Pioreactor dev blog #17 - Noisy data

Over the last two weeks that I’ve been here, I’ve been thinking about a whole variety of tests we can do with the Pioreactor (and adding them to our repository!). We’ve started with some basic experiments, changing parameters such as temperature and salt content to observe any changes in growth rate in yeast. 

This is not without its hiccups. We noticed some peculiar noise that occurred for only a few minutes at a time in some vials...

Pioreactor dev log #16 - Cables

Pioreactor dev log #16 - Cables
As we start to take a more critical eye at our project, we are revisiting parts of the Pioreactor that started as temporary hacks, but now need to be updated. Two really positive changes that we've decided on are our cable assemblies. Let me explain.